CORDIS Project
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This project focuses on the investigation of JBIR-23, a natural compound isolated from a bacterial source, which shows potential anti-cancer activity against malignant pleural mesothelioma. The aim is to synthesize JBIR-23 and its analogues to explore their effectiveness in treating this aggressive lung cancer.
Human malignant pleural mesothelioma is an aggressive (fatal) lung cancer which is always associated with previous asbestos exposure.
Typically symptoms do not appear until 35-40 years after the original exposure, with life expectancy then 12-18 months.
Given the great use of asbestos during the 20th century (before its long overdue ban in 1985) and this long latency period, it is no surprise that cases of mesothelioma continue to rise.
There is no known cure for mesothelioma: traditional chem…
QUEEN MARY UNIVERSITY OF LONDON
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