CORDIS Project
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This project investigates the role of the Jun N-terminal Kinases and c-Jun in neuronal regeneration after axonal injury. By using genetically modified mice, it aims to clarify how these proteins influence neuron survival and regrowth, contributing to our understanding of nerve repair mechanisms.
Interruption of axons results in a characteristic reaction of the injured neuron, the so-called axonal response, which aims to induce axon elongation and to achieve a re-construction of effective synapses.
Nerve fiber transection elicits a complex neuronal response that leaves neurons poised between death and regeneration.
Although the signals underlying this dichotomy are not fully understood, some are mediated by the induction of immediate-early transcription factors of the AP-1 family, a key…
CANCER RESEARCH UK LBG
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