CORDIS Project
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This project aims to improve treatment strategies for esophageal squamous cell carcinoma by investigating the genetic alterations affecting kinase activity in tumors. It focuses on evaluating the response of these tumors to CDK4 inhibitors and developing effective combination therapies using a multi-omics approach.
In decades, the 5-year survival rate of several cancers has barely been improved and the esophageal squamous cell carcinoma (eSCC) is not different with a rate around 25%.
In order to increase the survival, chemoradiotherapy prior surgery has become the reference for eSCC despite still a high mortality. eSCC tumors harbor a variety of genetic alterations directly or indirectly affecting the activity of kinases involved in signaling pathways, the cell cycle or the proliferation.
Evidence on how e…
UNIVERSITE LIBRE DE BRUXELLES
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