CORDIS Project
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This project aims to map the functions of kinetochores, which are critical for chromosome segregation during cell division. By studying their structure and dynamics, the research seeks to understand how errors in this process can lead to cancer and genetic diseases.
Equal partition of the genetic material to the daughter cells in mitosis requires the accurate anchorage of the mother cell s chromosomes to spindle microtubules.
This process takes place at kinetochores, complex scaffolds containing ~100 different proteins.
Conceptually, kinetochores can be viewed as performing four distinct but highly integrated functions: 1) they bind centromeric chromatin at a specialized protein-DNA interface; 2) they build a dynamic microtubule-binding interface that is ti…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy, Milano
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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