CORDIS Project
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KinCond investigates the role of protein kinases in Alzheimer's disease by examining their behavior within biomolecular condensates. The project focuses on the microtubule affinity-regulating kinase MARK2 and its influence on Tau phosphorylation, aiming to uncover mechanisms that could inform drug development.
Protein phosphorylation, mediated by kinases, plays a pivotal role in cellular regulation, with kinase dysregulation strongly associated with diseases like cancer, inflammation, and neurodegenerative disorders.
Alzheimer's disease (AD) represents a significant global health challenge as the population ages at an accelerating pace. A key pathological feature of AD is the accumulation of hyperphosphorylated Tau, which disrupts normal neuronal function.
Emerging evidence suggests that Tau undergoes…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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