CORDIS Project
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This project investigates the molecular mechanisms of kinetochore function using the yeast model organism, Saccharomyces cerevisiae. It focuses on understanding how kinetochores interact with spindle microtubules during cell division, which is crucial for accurate chromosome segregation and preventing genetic disorders…
The ability of spindle microtubules of to interact dynamically with centromeric chromatin is a critical feature of chromosome segregation and ensures the faithful distribution of genetic material.
Errors in this process lead to abnormal chromosome numbers and are a hallmark of cancer and birth defects.
The kinetochore is the key cell division organelle that enables high fidelity transmission of genetic information by coupling chromosomes to the plus-ends of spindle microtubules during mitosis an…
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