CORDIS Project
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This project studies natural killer cells and their receptors to understand their role in diseases like cancer and viral infections. It aims to develop new techniques for analyzing genetic variations in these receptors and to explore how viruses evade detection by these immune cells.
NK cells are relevant to many kinds of disease, including viral infection, autoimmunity, cancer, transplantation and reproduction.
The behavior of NK cells is controlled by a large number of different cell surface receptors, in a region on chromosome 19 called the LRC.
Some of these receptors, such as KIR, are highly variable in gene number and allele sequence in different individuals.
Many of them interact with HLA class I molecules, which are also highly polymorphic.
To understand and exploit…
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