CORDIS Project
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This project aims to elucidate the high-resolution structures of the human inward rectifier potassium channel Kir2.1, including a disease-related mutant, to understand how phosphatidylinositol-4,5-bisphosphate influences its function. The research combines advanced imaging and molecular dynamics simulations to explore…
The inward rectifier potassium (Kir) channels belong to a family of integral membrane proteins that selectively control the K+ ion permeation in cell membranes.
They are ubiquitously expressed throughout the human body and regulate the membrane electrical excitability and K+ transport in many cell types.
The gating of Kir channels is modulated by various intracellular ligands, with phosphatidylinositol-4,5-bisphosphate (PIP2) being an essential molecule to Kir channel activity in eukaryotes.
The…
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