CORDIS Project
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This project investigates how intracellular parasites, such as Plasmodium and Toxoplasma, secrete proteins to invade host cells. It aims to uncover the mechanisms of this secretion process, which is crucial for understanding and potentially disrupting infections.
Apicomplexan are obligatory intracellular parasites.
The ability of these parasites (Plasmodium, Toxoplasma) to cause disease depends on the coordinated secretion of specialized secretory organelles.
The rhoptries are particularly important, because they act as the apicomplexan equivalent of bacterial secretion systems.
They inject parasite proteins directly in the cytoplasm of host cells not only for invasion but also to hijack host functions crucial to establish and maintain infection.
However…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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