CORDIS Project
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This project focuses on a novel regulatory system in Pseudomonas aeruginosa that controls virulence gene expression in response to human signals. By characterizing this system, the research aims to develop new antimicrobial therapies targeting bacterial infections, particularly in cystic fibrosis patients.
The emergence and increasing prevalence of bacterial strains resistant to antibiotics demand the discovery of new therapeutic approaches.
Inhibition of pathogenesis by targeting bacterial virulence represents a promising alternative for antimicrobial therapy. A central requirement of bacterial virulence is the ability to tightly regulate virulence genes in response to host signals.
Besides the two-component regulatory system, cell-surface signaling (CSS) represents an important mechanism by whic…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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