CORDIS Project
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This project investigates the early cellular and molecular changes in liver cells that lead to chronic inflammation and hepatocellular carcinoma. Using a specialized mouse model, it aims to differentiate between cell-intrinsic and environmental factors affecting liver health, focusing on the roles of specific cellular…
Chronic liver inflammation has been shown to promote hepatocellular carcinoma (HCC).
However, the initial cellular and molecular events that trigger the inflammation are largely unknown.
The proposed study will provide a detailed characterisation of cellular processes that need to be deregulated in liver cells to cause inflammation.
For this purpose, a genetic mouse model that closely reproduces all the stages of inflammation-related HCC will be used.
This mouse exhibits a Liver Parenchymal Cell…
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