CORDIS Project
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This project aims to develop new anti-infective drugs by targeting the IspE enzyme, crucial for certain pathogens but absent in humans. It involves designing and synthesizing inhibitors to combat antimicrobial resistance, enhancing treatment options for infections.
Due to the current antimicrobial resistance crisis, addressing underexplored targets to afford anti-infective compounds with novel modes of action is urgently needed.
Antimicrobial resistance not only poses a threat to public health, but is a substantial cost burden on the healthcare system.
This proposal focuses on the design and synthesis of novel inhibitors of the target 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE).
IspE catalyzes the fourth step in the 2-C-methyl-D-erythritol 4-p…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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