CORDIS Project
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This project investigates how circulating monocytes differentiate into liver-resident macrophages known as Kupffer cells. By understanding the regulatory mechanisms and interactions within the liver, the research aims to inform therapeutic strategies for liver disorders.
We have recently shown that contrary to common hypotheses, circulating monocytes can efficiently differentiate into Kupffer cells (KCs), the liver-resident macrophages.
Using self-generated knock-in mice that allow specific KC depletion, we found that monocytes colonize the KC niche in a single wave upon KC depletion and rapidly differentiate into self-maintaining KCs that are transcriptionally and functionally identical to their embryonic counterparts.
This implies that: (i) access to the KC ni…
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