CORDIS Project
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LABEL-DIOX focuses on improving the efficiency of drug radiolabelling by promoting a late-stage carboxylation with labeled carbon dioxide. This user-friendly method utilizes abundant catalysts and operates under mild conditions, significantly reducing costs and waste in preclinical drug studies involving carboxylic aci…
Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step.
At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or…
FUNDACION PRIVADA INSITUTO CATALAN DE INVESTIGACION QUIMICA ICIQ
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
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