CORDIS Project
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This project explores the use of food-grade lactic acid bacteria to deliver oral vaccines for fish, specifically targeting the spring viraemia of carp virus. By utilizing zebrafish as a model, the project aims to understand immune response mechanisms and develop effective mucosal vaccines for mass delivery.
This project will provide a proof of principle that food-grade lactic acid bacteria (LAB) can be used as vehicle for oral vaccination of fish and will unravel the underlying mechanisms of memory formation in zebrafish.
We will engineer Lactococcus lactis to deliver a DNA- or protein-based prototype vaccine against spring viraemia of carp virus (SVCV).
The choice of virus and antigen is based on work showing that injection vaccination with DNA plasmids encoding the G protein of SVCV is highly suc…
WAGENINGEN UNIVERSITY
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