CORDIS Project
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This project investigates the interactions between metabolism and immune responses during Mycobacterium tuberculosis infection, focusing on how macrophages respond to lactate. The goal is to identify new therapeutic targets for tuberculosis treatment through a better understanding of host-pathogen dynamics.
Tuberculosis (TB) is a major global public health problem in which one-fourth of the world’s population is latently infected.
Host-directed therapeutics are a promising approach; however, we require a comprehensive understanding of how host-pathogen interactions impact signalling pathways and cellular responses to dictate disease outcome.Metabolic reprogramming of immune cells has been described during Mycobacterium tuberculosis (M.tb) infection, resulting in active glycolysis and lactate produc…
THE UNIVERSITY OF BIRMINGHAM
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