CORDIS Project
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This project investigates how lipid uptake by cancer cells influences their behavior, focusing on melanoma. It explores the role of oleic acid in activating a key signaling pathway and aims to understand the metabolic and biological consequences of this process on cancer cell phenotypes.
Tumors contain multiple subpopulations of cells some of which may contribute to therapeutic resistance.
Moreover phenotypic states in cancer (stem-like; invasive; proliferative; and differentiated) are dynamic and reversible, yet use many of the same signaling pathways implicated in activation and self-renewal of physiological stem cells.
Of these, the Wnt/b-catenin signaling pathway plays a major role in stem cell activation and differentiation, and is frequently constitutively activated in can…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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