CORDIS Project
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This project investigates how neurons navigate during development, focusing on the role of netrin and its receptors in guiding neuronal growth. By analyzing the molecular interactions and dynamics of growth cones, the research aims to enhance understanding of neurodevelopmental disorders and improve technologies for st…
Proper wiring and connectivity of the central and peripheral nervous system requires that during embryonic development neurons migrate and extend in the correct directions to connect to their targets.
Defects in the neuronal navigation machinery lead to a variety of neurodevelopmental disorders such as Hirschsprung’s disease, Kallmann syndrome, ACC and has been associated with autism spectrum disorders and epilepsy.
Neuronal navigation relies on a structure at the tips of neuronal extensions, te…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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