CORDIS Project
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This project focuses on the RNA-binding protein LARP4, which regulates mRNA stability and impacts cell migration, particularly in cancer. The goal is to understand how LARP4 influences gene expression during cell movement using human prostate cancer cell lines.
RNA-binding proteins (RBPs) act at multiple levels to regulate gene expression, including mRNA splicing, polyadenylation, localisation, stability, decay and translational efficiency and, although central to health and disease, much of this precise concerted regulation remains to be uncovered.
The recently discovered LARP4 is an RBP that affects mRNA stability and binds to polyA as well as the polyA-binding protein (PABP).
Intriguingly, LARP4 has recently been identified as a regulator of cell…
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