CORDIS Project
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This project aims to develop new methods for modifying aliphatic amines, which are vital in many pharmaceuticals. By utilizing advanced catalytic techniques, the research seeks to create novel drug analogues for testing in cancer treatment.
Aliphatic amines are central to the function of many biologically active molecules as evidenced by their prevalence in a large number of pharmaceutical agents.
The groups appended to these nitrogen atoms are crucial in determining the physical properties of the amine and are linked to how well it interacts with a biological target.
Despite the apparent simplicity of the aliphatic amine motif, the number of general methods that allow their late-stage functionalization directly on the bioactive co…
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