CORDIS Project
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This project investigates the dynamic organization of bacterial chromosomes using Hi-C data. By developing a unified statistical approach, it aims to understand how chromosome structure influences bacterial functions like replication and transcription.
The physical organization of bacterial chromosomes is inherently variable, with large conformational fluctuations both from cell to cell and over time.
Yet, chromosomes must also be structured to facilitate processes such as transcription, replication, and segregation. A physical description of this dynamic statistical folding of bacterial chromosomes remains largely elusive.
Hi-C experiments probe chromosome organization by measuring average contact frequencies of chromosomal loci pairs.
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