CORDIS Project
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This project aims to identify leukemia stem cells in acute myeloid leukemia by analyzing the expression of transposable elements. By leveraging high-throughput sequencing, the research seeks to improve patient classification and develop targeted therapies.
Acute myeloid leukemia (AML) is the most common of the acute leukemias among adults.
Relapsed AML patients are frequent but difficult to treat since effective therapies are limited.
This mediocre outcome can be partially explained by the presence of leukemia stem cells (LSC) that maintain an aberrant hematopoietic process. LSC in AML were traditionally thought to be solely CD34+CD38- cells.
However, recent studies demonstrated the presence of LSC in cell fractions thought to be non-tumorigenic.…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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