CORDIS Project
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This project explores the role of yolk sac-derived progenitors in childhood leukemias, particularly Down syndrome-associated transient myeloproliferative disease. By using induced pluripotent stem cells, it aims to uncover the developmental origins and molecular mechanisms of this condition to inform new therapeutic st…
This project aims at dissecting the contribution of yolk sac (YS)-derived haemopoietic progenitors to childhood leukaemias, whose early onset suggests an embryonic origin.
Using induced pluripotent stem cell (iPSC) differentiation, we will determine the origin of the Down syndrome-associated transient myeloproliferative disease (DS-TMD), paradigmatic example of perinatal malignancy. TMD, due to megakaryoblast hyperproliferation, has an in utero origin.
This supports the compelling hypothesis of…
OSPEDALE SAN RAFFAELE SRL
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