CORDIS Project
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This project investigates how leukocytes, the fastest migrating cells, adapt their movement in three-dimensional environments. It combines cell biology and biophysics to explore the molecular mechanisms behind their ability to switch between adhesive and non-adhesive states during migration, using advanced imaging and…
Cell migration is a universal feature of all metazoan life and crucially involved in most developmental, homeostatic and pathological processes.
Most efforts to understand its molecular and mechanical aspects were focused on the “haptokinetic” paradigm.
Here cells generate traction by coupling the protrusive and contractile forces of the actomyosin cytoskeleton via transmembrane receptors to the extracellular environment.
Our recent work demonstrated that leukocytes, the class of animal cells th…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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