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The LEWIS-PYR project focuses on developing a new catalytic technique for electrophilic aromatic substitution of azines, which are important in various chemical applications. This method aims to simplify reactions that are currently challenging due to the nature of azines.
Azines are nitrogen-containing aromatic rings of utmost synthetic relevance in natural products, pharmaceuticals, agrochemicals and materials science.
Although nucleophilic aromatic substitution techniques are routine, these methods require air-sensitive and highly reactive nucleophiles, in most instances organometallic reagents.
In sharp contrast, electrophilic aromatic substitutions are particularly difficult to the electron-poor nature of the azines, inevitably requiring harsh reaction condi…
FUNDACION PRIVADA INSITUTO CATALAN DE INVESTIGACION QUIMICA ICIQ
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
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