CORDIS Project
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The LEXSYN project focuses on understanding the role of lysosomal exocytosis in dendrites and its impact on synaptic plasticity. By investigating how neurons manage protein turnover, it aims to uncover mechanisms relevant to neurodegenerative diseases.
The extreme length and small caliber of neuronal processes entail complex local regulation of protein turnover.
In light of the high metabolic demand and dynamic protein exchange imposed by synaptic neurotransmission, several surveillance mechanisms should be in place to sense protein damage that will otherwise cause synaptic dysfunction.
However, it is still essentially unclear how local control of the metastable proteome, whose proteins have a high copy number and are crucial for synaptic func…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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