CORDIS Project
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This project focuses on identifying and understanding the role of Lgr6 as a potential marker for mammary stem cells. It aims to clarify the identity of these cells and their implications in breast cancer development.
The epithelial compartments of the mammary gland are thought to be derived from a tissue stem cell capable of self-renewal and differentiating into all cellular lineages of the mammary gland.
Detailed studies of normal and tumorigenic breast stem cells have proven rather cumbersome since these cells are rare and a high degree of purification is needed.
Several approaches to isolate mammary stem cells are based on the use of relatively unspecific surface markers, which are also expressed on diff…
KAROLINSKA INSTITUTET
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