CORDIS Project
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This project investigates the biological mechanisms of aging and how they affect the efficacy of anti-aging treatments. By using various model organisms, it aims to uncover the origins of aging-related failures and develop new therapeutic strategies to promote healthy aging.
Aging represents gradual organismal decline driven by accumulation of cellular and molecular damages including DNA damage and metabolic failures.
At young and middle age, these damages are mitigated by tailored repair systems, such as autophagy and DNA damage response.
The repairs can be triggered through adaptive stress responses induced by anti-aging interventions such as dietary restriction (DR) and DR mimetic metformin.
Recently, we found that loss of metabolic plasticity and repair activiti…
LEIBNIZ-INSTITUT FUR ALTERNSFORSCHUNG - FRITZ-LIPMANN-INSTITUT EV (FLI) LEIBNIZ INSTITUTE ON AGING - FRITZ LIPMANN INSTITUTE EV (FLI)
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