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The LIMITS project aims to explore the role of lipid droplets in microglia following ischemic stroke. By developing new mouse models, it seeks to identify potential therapeutic targets and improve understanding of the inflammatory response in stroke recovery.
Each year, 1.1 million inhabitants of Europe suffer stroke.
Stroke leads to extensive neuronal loss and results in an environment filled with cellular debris, notably myelin debris.
The clearance of this debris by microglia is crucial for restoring homeostasis, but it can overwhelm their phagocytic function.
Consequently, damaged areas often exhibit microglia with cytoplasmic inclusions known as lipid droplets (LDs).
Recent findings by one of the supervisors indicate that microglia in young mice…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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