CORDIS Project
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This project investigates the role of long intergenic non-coding RNAs in chromatin changes during aging and their potential involvement in acute myeloid leukemia. It aims to identify new molecules that could influence cancer progression and stem cell aging.
Changes in chromatin structure are observed during aging and are often a critical step during tumorigenesis.
The class of long intergenic non-coding RNAs (lincRNA), has emerged as an important regulator of chromatin structure during normal differentiation, and recently has been implicated in the disregulation of chromatin structure observed in several solid tumours.
These lincRNAs could represent an important new class of oncogene.
We propose to investigate a potential involvement of lincRNAs in…
Université Paris Diderot-Paris 7
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