CORDIS Project
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This project investigates the role of immune cells in the liver during the early stages of dyslipidemia, focusing on how these interactions contribute to nonalcoholic fatty liver disease and atherosclerosis. Using advanced mouse models, it aims to identify mechanisms that could lead to earlier detection and interventio…
The metabolic syndrome and its several manifestations have currently taken a tremendous toll on many aspects of society.
Nonalcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome while atherogenic dyslipidaemia, and especially apolipoprotein B (ApoB)-containing lipoproteins, is considered the major causal mechanism in atherosclerosis initiation and progression.
By employing novel humanized mouse models that can be rendered acutely dyslipidemic, we have…
KAROLINSKA INSTITUTET
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