CORDIS Project
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This project investigates the role of N-acylethanolamines in the anchorage of alpha-synuclein to cell membranes, aiming to understand how changes in lipid composition affect the spread of misfolded proteins in neurodegenerative diseases like Parkinson’s. It combines pharmacological and molecular biology techniques to e…
Neurodegenerative pathologies (NDs), including Parkinson’s disease, represent a huge burden worldwide from a health, economical and societal point of view.
However, the physiopathology of these diseases is not well understood, making the discovery of a cure extremely hard. A common feature of NDs is the accumulation of misfolded proteins such as alpha-synuclein (asyn) in different types of proteinaceous aggregates, the formation of which follows a prion-like spreading mechanism.
In this context,…
INSTITUT PASTEUR
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