CORDIS Project
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This project focuses on developing lipid-based scaffolds to enhance the delivery and effectiveness of antibodies targeting mutated RAS proteins in cancer therapy. By creating lipidic antibody constructs, the project aims to improve cellular uptake and stability, ultimately providing a novel approach to treat cancers as…
The RAS family of GTPases is associated with important signalling events responsible for cell growth, proliferation and survival.
Mutated RAS are, nevertheless, associated with uncontrolled cell proliferation in 30% of human cancers.
Intracellular antibodies targeting oncogenic RAS proteins constitute promising anticancer therapeutics.
Nevertheless, their intrinsic cytosolic instability as well as the lack of methods enabling their proper cellular uptake and localization highly limit their use a…
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