CORDIS Project
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This project investigates metastasis-initiating cells in tumors, focusing on their unique lipid metabolism and sensitivity to dietary fats. It aims to understand how these cells promote metastasis and their response to high-fat diets, using advanced models and analyses in melanoma, oral, and breast cancer.
We have recently identified metastasis-initiating cells (MICs) in several types of tumors (Nature, 2017)1.Intriguingly, MICs: (i) are exclusive in their ability to generate metastases when transplanted; (ii) express thefatty acid channel
CD36 and have a unique lipid metabolic signature; (iii) are exquisitely sensitive to thelevels of fat in circulation, thus providing a link between the predisposition of metastasis and dietary fat; (iv)are highly sensitive to CD36
inhibition, which almost comple…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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