CORDIS Project
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This research explores a novel signaling pathway in the brain involving lysophosphatidic acid and its receptor, PRG-1. The project aims to understand how this pathway affects neuronal transmission and its implications for brain function and psychiatric disorders.
We have recently reported on a novel mode of modulation of neuronal transmission at the glutamatergic junction.
This signaling pathway involves lysophosphatidic acid (LPA) acting via presynaptic LPA2 receptors.
This is in turn controlled by a molecule which we named plasticity related gene-1 (PRG-1, Bräuer et al., Nat Neurosci 2003) from the postsynaptic side (Trimbuch et al., Cell 2009). PRG-1 is a brain-specific membrane protein related to lipid phosphate phosphatases (LPPs) with a selective e…
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
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