CORDIS Project
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This project investigates how embryonic stem cells maintain their unique properties and differentiate into various cell types. By employing live cell imaging and advanced microscopy techniques, it aims to understand the dynamics of chromatin structure and transcriptional regulation during differentiation processes.
Owing to their unique ability to self-renew indefinitely, as well as their capacity to differentiate into multiple cell types of all three germ layers, embryonic stem (ES) cells hold great promise both as therapeutic agents in the clinic and as research tools in the lab.
One of the main challenges in the field is understanding how stem cells achieve their remarkable potential.
Recent efforts by us and others have shown that chromatin itself serves as a major contributor to ES cell identity and p…
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