CORDIS Project
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This project investigates the role of long non-coding RNAs in human adipocytes, focusing on their interaction with metabolic enzymes that regulate lipid storage and fatty acid release. By utilizing advanced techniques, it aims to uncover how these RNA molecules influence metabolic processes in health and obesity-relate…
Energy is stored in adipocytes as a large uniocular lipid droplet, which can be broken down into fatty acids (FAs) and released into the circulation when needed.
This specialised lipid storage and breakdown requires dynamic organisation of metabolic enzymes and cofactors around the large lipid droplet for metabolic homeostasis.
In obesity, the adipocyte dysfunctions, resulting in high spontaneous release of FAs.
This chronic release and elevation of systemic FAs is a major driver of systemic ins…
KAROLINSKA INSTITUTET
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