CORDIS Project
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This project investigates the mechanisms of lymph node remodelling, focusing on fibroblastic reticular cells and their role in immune responses. It aims to understand how these cells change during lymph node expansion and how homeostasis is restored after immune activation.
Lymph node swelling is a classical hallmark of immunity.
This expansion is observed by doctors, researchers and patients, yet as obvious as this process is, our understanding of the remodelling mechanisms involved are in their infancy.
Lymph node remodelling is rapid and yet completely reversible, occurring countless times throughout our lifetimes.
The purpose of this proposal is to understand how lymph node remodelling occurs and is resolved, repeatedly; to understand immunity in a whole organ…
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