CORDIS Project
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This project focuses on developing synthetic methods to create antitumor antibiotics, specifically Lomaiviticins A and B, and Kinamycin C. These compounds are known for their ability to cleave DNA and show promise against various cancer cell lines, potentially offering new therapeutic options in cancer treatment.
The proposed research describes a strategy for the convergent synthesis of diazobenzofluorene containing antitumor antibiotics Lomaiviticins A and B as well as the structurally related Kinamycin C.
They are potent DNA cleaving agents and exhibit remarkable activity against a broad spectrum of cancer cell lines.
These structurally novel antitumor antibiotics have a unique cytotoxicity profile, compared to other known DNA-damaging anticancer drugs such as adriamycin and mitomycin C, which may su…
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