CORDIS Project
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This project investigates the role of protein aggregation in neurodegenerative diseases like Huntington's and Parkinson's. By using an automated microscope system, it tracks individual neurons to understand how protein accumulation affects neuronal survival and whether this aggregation is a protective response or a cau…
Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) are the most common human neurodegenerative diseases.
Each features an abnormal accumulation of proteins, but whether the aggregation leads to neuronal death is controversial. HD is caused by a single mutation that increases the number of CAG repeats.
Mutant huntingtin (htt) forms intraneuronal inclusion bodies (IBs).
To determine if IBs are pathogenic, incidental, or a beneficial coping response, we developed an au…
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
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