CORDIS Project
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This project investigates how DNA is organized within chromosomes through a process called loop extrusion, driven by specific protein complexes. By examining the mechanisms and regulation of this process, the research aims to enhance understanding of genetic information maintenance and its implications for cellular fun…
Life and evolution of organisms relies on the maintenance, integration, propagation, and readout of genetic information.
This information is stored in chromosomes that have a specific three-dimensional structure, a condensed yet accessible form of DNA that is dynamically folded during the lifespan of cells.
How DNA is folded within chromosomes has however remained a mystery.
It has been proposed that this is achieved by a process of loop extrusion in which SMC (Structural Maintenance of Chromoso…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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