CORDIS Project
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This project aims to combat antimicrobial resistance by targeting the Lpt protein complex in Gram-negative bacteria, which hinders antibiotic effectiveness. By employing biophysical and computational methods, the research seeks to understand the transport mechanism of lipopolysaccharide, paving the way for new drug dis…
Antimicrobial resistance is a global public health threat and a top priority concern in Europe with estimated 1,27 million annual deaths worldwide and 35,000 in Europe.
Many of these deadly infections are caused by resistant Gram-negative bacteria which are undermining our therapeutic options because antibiotics are no longer effective.
These bacteria are coated by two membranes where the one exposed to the environment is made of lipopolysaccharide—a toxic glycolipid which forms a barrier hamper…
UNIVERSITE GRENOBLE ALPES
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