CORDIS Project
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This project investigates the role of the bone marrow microenvironment in maintaining leukemia stem cells, particularly in MLL-induced leukemias. It aims to understand how specific cells and signals within this niche contribute to cancer progression and to explore potential therapeutic strategies targeting these intera…
The presence of self-renewing “cancer stem cells” responsible for tumour initiation and maintenance has been well defined in multiple types of solid and haematologic tumours; however, our knowledge of their biology is very limited.
While it is believed that leukaemia stem cells (LSC) – like normal haematopoietic stem cells (HSC) – depend on the interaction with a specialized microenvironment or ‘niche’ for their self-renewal and maintenance, the identity and function of this leukaemic niche are…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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