CORDIS Project
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This project aims to redefine our understanding of lymphatic vessels by studying their development and function in zebrafish. It investigates the cellular origins and roles of lymphatic endothelial cells, focusing on their involvement in health and disease, and aims to establish a new paradigm for lymphatic biology.
For many years, lymphatic vessels have been viewed as inert fluid conduits whose open structure allows for passive flow of antigens, proteins and cells from peripheral tissues to lymphoid organs.
Yet, recent discoveries highlighting novel functions and heterogeneous origins of the lymphatic endothelium, call for reevaluation of the passive lymphatic-vessel paradigm.
During the past decade, we have used the zebrafish (ZF) to detail the cellular and molecular events underlying the development of t…
WEIZMANN INSTITUTE OF SCIENCE
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