CORDIS Project
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This project investigates the genetic factors contributing to human B cell lymphomas, particularly focusing on the role of Epstein-Barr Virus in cancer development. It employs a novel genetic tool to study mutations in B cells and their implications for lymphoma pathogenesis.
Human B cell lymphomas including multiple myeloma and Hodgkin¿s disease are frequent malignancies and a major clinical problem.
Their high incidence is due to special features of normal B cell development that promote chromosomal translocations and other genetic alterations.
Another contributing factor is Epstein-Barr-Virus (EBV), a B cell-transforming virus endemic in humans. EBV-infected cells are usually eliminated by the immune system, but in immunosuppressed (post-transplant or AIDS) patien…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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