CORDIS Project
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This project investigates how genetic translocations affect the three-dimensional structure of the genome and contribute to Non-Hodgkin lymphoma. By creating specific cell models, it aims to understand the relationship between genome architecture changes and tumor formation, potentially revealing new therapeutic target…
A central goal in cancer research is to identify the molecular mechanisms underlying tumor formation, such as translocations that result in expression of fusion genes or proto-oncogenes located at the translocation breakpoints.
While the consequences of this erroneous expression have been widely studied, other effects of translocations remain largely unexplored.
Nevertheless, these can provide vital new insights into tumorigenesis. I hypothesize that translocations disturb the global 3D genome a…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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