CORDIS Project
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This project investigates the regulation of lipid metabolism in lysosomes, which are crucial for cellular health. By understanding the mechanisms of lipid composition and export in lysosomes, the research aims to develop new therapeutic strategies for diseases linked to lysosomal dysfunction, including neurodegenerativ…
Lysosomes are the central degradative organelle of all cells and function as logistic centres of cellular metabolite flux.
Their dysregulation underlies ~70 monogenetic lysosomal storage disorders, metabolic syndromes, neurodegenerative maladies, and aging, thus affecting an ever-growing portion of the human population. A frequent denominator in these pathophysiological conditions is the deposition of lipids and lipid metabolites in the lysosomal lumen which leads to the accumulation of dysfunct…
MEDIZINISCHE UNIVERSITAT INNSBRUCK
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