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LYSOSOMICS investigates the lysosome's role beyond waste disposal, focusing on its regulatory functions in health and disease. The project employs advanced genetic techniques to explore lysosomal biology and its implications for neurodegenerative disorders.
For a long time the lysosome has been viewed as a “static” organelle that performs “routine” work for the cell, mostly pertaining to degradation and recycling of cellular waste.
My group has challenged this view and used a systems biology approach to discover that the lysosome is subject to a global transcriptional regulation, is able to adapt to environmental clues, and acts as a signalling hub to regulate cell homeostasis.
Furthermore, an emerging role of the lysosome has been identified in ma…
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