CORDIS Project
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This project focuses on the role of metabolic processes in epigenetic modifications, particularly through the use of a compound called 4'-phosphopantetheine. It aims to develop tools for inducing histone modifications, potentially leading to new therapeutic strategies for genetic disorders linked to metabolism.
Post-translational chemical modifications to histone proteins – the storage units of DNA – influence gene expression electrostatically and through specific protein-protein interactions, the study of which is known as epigenetics.
Although many enzymes have been identified which add, remove or recognise these modifications, the implication of metabolism in the induction of epigenetic states is a recent development – particularly highlighting acetyl coenzyme A (CoA) as the sole donor for acetylati…
ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO
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