CORDIS Project
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This project aims to uncover the molecular mechanisms behind autoimmune diseases, particularly focusing on large granular lymphocyte leukemia. It investigates how mutations in immune cells contribute to disease progression and seeks to identify potential therapeutic targets.
Molecular pathogenesis of most immune-mediated disorders, such as of autoimmune diseases, is poorly understood.
These common maladies carry a heavy burden both on patients and on society.
Current therapy is non-targeted and results in significant short- and long-term adverse effects.Large granular lymphocyte (LGL) leukemia is characterized by expansion of cytotoxic T- or NK-cells and represents an intriguing clinical continuum between a neoplastic and an autoimmune disorder.
Patients suffer from…
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